Aedes aegypti is considered the main vector of a group of arboviruses responsible for dengue and yellow fever. In searching to find natural products that could be employed in the effective control of this mosquito, the larvicidal activities of crude extracts from 15 seaweed species from northeastern Brazil have been determined. Extracts of Canistrocarpus cervicornis, Laurencia dendroidea, Hypnea musciformis and Chaetomorpha antennina at concentrations of 300ppm showed =50% mortality against fourth instar larvae of A. aegypti. The strongest larvicidal activities (>91% mortality at 50ppm) were obtained with extracts of L. dendroidea. A halogenated sesquiterpene, identified at elatol was isolated by sequential fractionation of the n-hexane extract of this species of seaweed, which exhibited potent larvicidal activity with an LC50 value of 10.7 ppm.    The large scale isolation of elatol from seaweed could represent an interesting prospect for the production of a novel agent against the dengue mosquito.

Larvicidal activity of seaweeds from northeastern Brazil and of a halogenated sesquiterpene against the dengue mosquito (<i>Aedes aegypti</i>)

244th National Meeting (2012)

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Larvicidal activity of seaweeds from northeastern Brazil and of a halogenated sesquiterpene against the dengue mosquito (Aedes aegypti)