Recent studies from our group  have identified  bioactive stilbenoids, including resveratrol oligomers, from previously uninvestigated Carex species collected in Pennsylvania, United States. This is of great interest to the nutraceutical industry given that resveratrol, a constituent of grape and red wine, has attracted immense research attention due to its potential human health benefits. Here Carex vulpinoidea seeds were evaluated using cytotoxicity-assay guided isolation against human colon cancer (HCT-116; Caco-2) cells. Hopeaphenol (IC50 = 2-5 �M), a resveratrol tetramer, was identified as a major bioactive compound along with other polyphenols including  quercetin and eriodictyol.  Thus, given the wide prevalence and underutilization of Carex species in the United States, these plants may have potential application in the nutraceutical industry. Also, this is the first reported study of C. vulpinoidea species.

Bioassay-guided isolation of cytotoxic constituents from <i>Carex vulpinodea</i> seeds

244th National Meeting (2012)

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Bioassay-guided isolation of cytotoxic constituents from Carex vulpinodea seeds