Gallotannins are hydrolyzable tannins found in berries, tea, wine and other plant foods. Here we conducted anticancer and structure activity related (SAR) studies of  twelve gallotannins isolated from sugar (Acer saccharum) and red (Acer rubrum) maple species which are primarily used to produce maple syrup.  The gallotannins, ginnalins A-C and maplexins A-I, differ in the number of galloyl groups connected to a 1,5-anhydro-D-glucitol core. The gallotannins were evaluated for  antiproliferative effects against human colon (HCT-116) and breast (MCF-7) cancer cells. While the gallotannins with one galloyl group were not active, those with two galloyls were more active than those with three galloyls (IC50 = 28-50 vs. 64-112  mg/mL). Also, maplexins C-D, which contained two galloyls, induced apoptosis and arrested cell cycle (in S-phase) of the cancer cell lines. However, ginnalin A, which also contained two galloyls, arrested cell cycle but did show apoptogenic effects against the cancer cells. Thus, the anticancer effects of maple gallotannins are influenced by the number of galloyl groups and are mediated by apoptosis and cell cycle arrest.

Anticancer and structure activity related (SAR) studies of maple gallotannins

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.