Illegal compounds such as drugs and its synthetic analogues have been detected in foods until a recent date in Korea. Especially, unknown compounds that have the modified chemical structure of anti-impotence drugs such as sildenafil, vardenafil, and tadalafil were frequently detected in various foodstuffs. Illegal compounds that have modified chemical structure of the drugs have been used to avoid the government inspection. The adulteration of foods with drug analogues is potentially dangerous for human health because it is not proved their safety at all. In order to ensure food safety, we investigated the actual condition of the suspected samples and monitored about 112 internet sales foods and domestic retail foods. Two simultaneous analytical methods were established using HPLC/PDA and confirmed with LC/MS for 31 analogues and 5 anti-impotence drugs. Anti-impotence drugs and its analogues were detected in 16 items. Tadalafil was detected with range of 4,139~65,315mg/kg in 8 items. Sildenafil with range of 3,621~394,438mg/kg in 8 items. Anti-impotence drugs analogues such as octylnortadalafil and demethylsildenafil was detected with range of 1,174~214,094mg/kg in 4 items. Hydroxythiohomosildenafil was detected 14,717mg/kg in one items. This research was supported by Grant Number 11161kfda151 and 12161kfda111 form the KFDA.

Monitoring anti-impotence drugs and its analogs in foods

244th National Meeting (2012)

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