Planar oxide supports can be elaborated with two-dimensionally fluid phospholipid bilayers for understanding the mechanistic biochemistry of model cell membranes as well as the design of biosensor devices. We have employed these architectures inside lab-on-a-chip platforms to study the interactions of proteins, peptides, and ions. The results reveal that the equilibrium dissociation constants of interaction can be tuned over a wide range of values that depend strongly on the concentration and specific chemistry of negatively charged lipids. Results will be presented from sum frequency generation, fluorescence microscopy, fluorescence quenching, and electrophoretic mobility measurements.

Studying the interactions of peptides, proteins, and ions on supported lipid bilayers

244th National Meeting (2012)

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