The removal of heavy-metal impurities is an important task in pharmaceutical and fine chemical production [1]. It remains challenging, since the acceptable ruthenium content should not exceed 10 ppm in an API [2]. Furthermore, the applicability and the cost-efficiency of the purification method are of high importance. Membrane processes are a well-known separation technique widely used on the industrial scale in aqueous media for water treatment as well as in the food industry for both concentration and specific extractions of target molecules [3].The integration of nanofiltration within the homogeneous catalytic process [4] of olefin metathesis represents an innovative and soft route of puriffication. In our work we applied specially modyfied ruthenium catalysts and nanofiltration as a efficient and cheap way of purification of metathetic products [5]. Our catalysts can be reused up to 5 times without significant lose of activity.JC thanks the Foundation for Polish Science for financial support. The project Ventures/2011�7/3 is realized within the Ventures program of Foundation for Polish Science, co-financed from European Union, Regional Development Fund References:1. Czaban, J.; Torborg, C.; Grela, K.; in Sustainable Catalysts: Challenges and Practice for the Pharmaceutical & Fine Chemicals Industries (Eds.: M. Hii, P. J. Dunn, J. K. Krische), Wiley-VCH, in print2.The European Agency for the Evaluation of Medicinal Products, http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2009/09/WC500003586.pdf3. Schafer, A. I.; Fane, A. G.; Waite T. D. (Eds.), Nanofiltration-Principles and Applications, Elsevier, Amsterdam, The Netherlands, 2003 .4.  Janssen, M.; Muller, C.; Vogt, D. Green Chemistry 2011  , 13, 2247.5. a) Azap, C., Wolf, D., Abbenhuis, H. C. L., Gerritsen, G., Wilting, J., Leszczynska, K., Grela, K., Czaban, J., Wojtasiewicz, A. Polysilsesquioxane (POSS)-linked Imidazole-based Carbene and Phosphine Ligands for Transition Metal Catalysts Application Patent No. WO2011 EP52885 20110228; b) Azap, C., Wolf, D., Abbenhuis, H. C. L., Gerritsen, G., Wilting, J., Leszczynska, K., Grela, K., Czaban, J., Wojtasiewicz, A. Polyhedral Oligomeric Silesquioxane (POSS)-linked Ligands. Patent No. EP20100155081 20100301; c) Ahmadi, A.; McBride, C.; Freire, J. J.; Kajetanowicz, A.; Czaban, J.; Grela, K. J. Phys. Chem. A 2011  , 115, 12017.

New possibilities of purification of metathesis reaction.

244th National Meeting (2012)

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