We report here the systematic characterization of coupled water-proteins interactions and dynamics around a series of different protein architectures from small structural motifs, to mini proteins, and finally to different globular second structures with different size and flexibility. A series of correlations between the dynamics and protein properties was observed. These results revealed the wide range of heterogeneous dynamics with multiple time sales but are well correlated with the protein structures, dynamics and even function.

Water-protein interactions and dynamics around different protein architectures

244th National Meeting (2012)

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