Mass spectrometry is widely used by industry in research and development efforts that lead to novel agricultural chemicals. The requirements and acceptability of mass spectrometry-based analytical methods are variable. Several examples of DuPont analytical methods will be presented: from early agrochemical discovery research, to regulatory studies for product registration, and post-registration product support. These diverse methods are based on chromatography/tandem mass spectrometry and high-throughput flow injection/tandem mass spectrometry to analyze active ingredients, such as sulfonylureas, anthranilic diamides, and carbamates at part-per-billion levels in complex environmental and food matrices. The challenges of optimizing quantitative analysis quality (i.e., accuracy and precision), sample analysis throughput, and sensitivity to meet the objectives of agrochemical research and comply with regulatory guidelines will be highlighted. In addition, current collaborative research programs that pursue the development of novel methods of analysis and the improvement of analytical technology at DuPont will be briefly discussed.

Mass spectrometry-based methods for trace-level analysis in industrial and agrochemical research

244th National Meeting (2012)

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