The incorporation of radioactive isotopes into pyrogallol[4]arene-based metal-organic nanocapsules (MONCs) is a valuable, albeit underutilized tool towards the study of these compounds.  Radiochemical methods not only aid in the determination of empirical data that is difficult to obtain by other means but also introduce a viable pathway into the investigation of these compounds as biocompatible tools for imaging and/or therapy.  In this study, copper-64 was used to study the hexameric MONCs derived from several C-alkylpyrogallol[4]arenes (PgCns). Synthesis of PgC-based MONCs in a medium containing 64Cu led to its inclusion into the oxometal capsular shell.  This material was then used to determine the yield, solubility, and stability of these compounds under varying conditions.  The conditions employed included: the presence of other transition metal ions in solution, including free Cu2+, various chelating agents, and various solvent systems, including those of a biologically-relevant nature.

Incorporation of Cu-64 into copper-seamed pyrogallol[4]arene nanocapsules

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.