Cells tout diverse carbohydrate coatings that either aid or subvert animal and human immune responses. For this reason, carbohydrate-based materials are promising as biomaterials. Unfortunately, the use of carbohydrate materials from natural sources are complicated by their isolation as microheterogeneous mixtures and sometimes by the low relative abundances of particular structures needed for a specific biological response. This talk will focus on the design and synthesis of carbohydrates, including by automated oligosaccharide synthesis, and on linkers and conjugation strategies for these sugars for their incorporation into polymeric biomaterials.

Carbohydrate synthesis and the design of immunomodulatory materials

244th National Meeting (2012)

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