The de novo asymmetric syntheses of the glycosylated natural products and analogues from achiral starting materials have been developed. The asymmetry of the carbohydrate portion of these products was installed by means of the Noyori reduction, diastereoselective palladium catalyzed glycosylation and subsequent diastereoselective post glycosylation transformation. This approach has been widely successful in term of the range a structural motifs it has been applied. Our latest synthetic effort along with subsequent biological evaluations will be presented.

De novo synthesis of carbohydrate based natural products for medicinal chemistry

244th National Meeting (2012)

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