The search for molecules with broad-spectrum antibacterial activity has led to natural sources for new pharmaceutical advances. Plant material has proven to be a reservoir of bacterial inhibition. This research has focused on water-soluble compounds and has found positive bacterial inhibition from multiple sources. This experiment is designed to ascertain a specific mode of action for inhibition. Penicillin inhibits the transpeptidation reaction by binding to the bacterial cell wall proteins. In order to determine plant extract binding to these proteins, isolated cell wall proteins were subjected to SDS-PAGE. Binding of the active extract to a specific protein would alter that protein's electrophoretic mobility, and has identified several possible targets.

<i>Staphylococcus aureus</i> cell wall proteins targeted by antibacterial plant extracts

244th National Meeting (2012)

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Staphylococcus aureus cell wall proteins targeted by antibacterial plant extracts