Gamma-synucleins (gamma-syn) belong to a small, soluble, highly conserved group of neuronal proteins implicated in both neurodegenerative diseases and cancer. They share sequence homologies and structural properties whose biological functions are still unclear. However their involvement in these diseases may provide insights into the pathological processes resulting from their effect, and present the possibility to serve as potential targets for early diagnosis and treatment. Recently, elevated levels of gamma-syn proteins were detected in advanced stages of cancer. Furthermore, studies to date indicate that overexpression of gamma-syn compromises normal mitotic checkpoint controls, resulting in multinucleation as well as faster cell growth. Gamma-syn has also been shown to promote invasion and metastasis in animal models as well.  These observations raise questions about the involvement of gamma-syn in the process of tumorigenesis and metastasis, and current efforts try to use them as markers in assessing breast cancer progression.

Expression of gamma-synuclein protein in cancer cells

244th National Meeting (2012)

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