Supramolecular chirality, also denoted as artificial chirality or 'chirogenesis' provides amplified opportunities for synthetic chemists in the area of homogeneous catalysis,  determination of absolute configurations of substrate molecules, and materials chemistry. This concept has grown over the last years, and currently has matured into a field of science at the forefront of supramolecular chemistry. Here we report on various generations of bis-metallosalen complexes hosts comprising of a pro-chiral biphenyl spacer that upon binding of suitable ditopic ligands/substrates results in the expression of one chiral host conformer. This has been particularly useful for the determination of the absolute configurations of carboxylic acids and the binding of various mono- as well as ditopic substrates marking these hosts as highly versatile systems that can be designed for particular applications.

Artificial chirality: First and second generation bis-metallosalens for binding of mono- and ditopic chiral guests

244th National Meeting (2012)

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