  Aromatic amines are common features in biologically active compounds; however, synthetic methodologies for direct C-H amination are mostly restricted to arene substrates that bear directing groups. Our approach uses suitable ancillary ligands in combination with Pd catalysts to amidate simple arenes in the presence of an oxidant. Our studies explore the oxidant, ligand, and substrate scope of this new C-N bond formation process that proceeds in a single step.

Non-directed Pd-catalyzed C-H amination of arenes

244th National Meeting (2012)

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