Neurotrophins are endogenous peptides responsible for development and repair of neurons in the brain. Depletion of neurotrophins could potentially lead to neurodegenerative disorders. Direct delivery of neurotrophins to the brain is not a practical solution.  Therefore, there is an urgent need to discover safe therapeutic agents that can enhance the expression of neurotrophins in the brain. Carnosic acid has been reported to have the potential to enhance the expression of neurotrophins in the in vitro cell line models. Further, we investigated the brain bioavailability of carnosic acid in the brain by microdialysis sampling, following i.p and intranasal administration. The levels of Nerve generation factor (NGF) and Brain derived neurotrophic factor (BDNF) was found to be significantly higher in treated rats than in the control rats. Pharmacodynamic investigations were performed in depression induced rat model (BDNF depleted rats).

Potential agents to enhance the expression of neurotrophins in the brain

244th National Meeting (2012)

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