The exploration of gold or silver coated magnetic nanoparticles (M@Au or M@Ag) as a core@shell type of nanoprobes combines the advantages of magnetic character of the core for bioseparation or targeting and the controllable surface chemistry of the gold or silver shell.  This combination is important for achieving the specific biomedical function, but also the desired biocompatibility or antibacterial ability.  In this presentation, recent results of our investigations of the synthesis, characterization and application of M@Au and M@Ag nanomaterials as biological nanoprobes will be discussed.  Examples will focus on bioseparation of DNA- and protein-mediated assemblies and inactivation of bacteria.  In addition to the magnetic separation function, the spectroscopic functional properties of the core-shell magnetic nanomaterials as surface enhanced Raman scattering (SERS) probes terms of the particle size, morphology, composition and surface chemistry will also be discussed.

Functional core@shell magnetic nanoparticles as biomedical probes

244th National Meeting (2012)

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