Peptide coated magnetic mesoporous silica nanoparticles were synthesized for fluorescent and MR dual imaging in addition to drug delivery. First, magnetic iron oxide nanoparticles were encapsulated in mesoporous silica shell and Rhodamine B dye was conjugated to the silica shell. Particle diameter of core-shell structure was found to be around 45 nm based on TEM. However, hydrodynamic size of the particles is around 200 nm and they precipitate in a few minutes. In order to improve their solubility, we coated the particles with lauryl-PPPPGE-OH, amphiphilic peptide non-covalently. Hydrodynamic size of the peptide coated particles is around 55 nm, and they are stable in water for several days without significant increase in the size. Furthermore, particles did not cause any significant cytotoxicity to MCF-7 breast cancer cell line up to 100 �g/mL. We also studied cellular uptake, fluorescence and MR imaging capabilities of both peptide coated and bare nanoparticles.

Improved solubility and biocompatibility of peptide coated magnetic mesoporous silica nanoparticle theranostic agents

244th National Meeting (2012)

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