Since their introduction four decades ago, soft contact lenses have become an extremely popular medical device, composing over 90% of the contact lens market today. Recent microbial keratitis outbreaks among soft contact lens wearers in the United States and around the world prompted regulatory science research at FDA to address this public health challenge. Multidisciplinary research was conducted to support updating the FDA lens grouping system and study material-solution interactions. This talk will discuss our research efforts in the areas of materials chemistry and bioanalytical chemistry, the project's contribution to current regulatory science knowledge, and potential implications that the data has for public health. In particular, we will discuss 1) discoveries about the properties of silicon hydrogel contact lens materials, and 2) new insights into preservative uptake and depletion.

Contact lens materials and multipurpose solutions: Lessons learned from laboratory research

244th National Meeting (2012)

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