Poly(ethylene oxide) (PEO) polymers have been of great interest to biomaterial scientists for many years due to their biocompatible properties. PEOs with a broad range of end-functions are found in wide variety of applications such as drug delivery, tissue engineering scaffolds, surgical gel sealants and others. In this work we aim at synthesizing a poly(ethylene oxide) macromonomer carrying protected aldehyde end groups for conjugation at a latter stage. This was prepared by anionic polymerization of ethylene oxide with a protected aldehyde initiator 2-(3-hydroxy propyl)-5, 5-dimethyl-1, 3-dioxane followed by the reaction with 4-vinylbenzyl chloride. Radical homopolymerization in water / methanol system yielded branched PS-PEG polymer having dioxane ends. This was deprotected under acidic conditions to yield the desired branched PEG-CHO polymer.

Novel efficient synthesis of branched poly(ethylene oxide) (PEO) having aldehyde functionalised side chains

244th National Meeting (2012)

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