A domino approach of Heck coupling was used to synthesize various fluorinated as well as nonfluorinated styrene derivatives from aryl halides in good to excellent yields. Each of the methods discussed is an example of a �domino� approach where more than one synthetic transformation is carried out in one pot. These new synthetic methodologies have various advantages over previously known methods in terms of use of �green� solvent, water (for nonfluorinated styrenes) and absence of gaseous reagents such as 3,3,3-trifluoropropene and 1-fluoroethene (for fluorinated styrenes). In addition, these methods have phosphine-free catalytic systems, shorter reaction times and absence of any additives.

Domino approach of Heck coupling for the synthesis of fluorinated and nonfluorinated styrenes

244th National Meeting (2012)

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