In contrast to methods for the palladium-catalyzed synthesis of aryl fluorides, reports of Pd-catalyzed aliphatic C�F bond formation are relatively rare.  This presentation will describe the asymmetric and regioselective synthesis of allylic fluorides by Pd(0) catalysis with silver(I) fluoride as a nucleophilic fluorine source.  Mechanistic studies that elucidate the nature of C�F bond formation will also be presented, along with extensions of this mechanism to cascade reactions for the synthesis of fluorinated heterocycles. 

Palladium-catalyzed aliphatic carbon–fluorine bond formation

244th National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.