Sphingosine-1-phosphate (S1P) is a lipid signaling molecule that is involved in multiple biological processes.  In order to elicit a functional response, S1P can bind to any of five specific G protein-coupled receptors (GPCRs), numbered S1P1 through S1P5, which are differentially expressed across a variety of tissues.  Agonists of the S1P1 receptor have been shown to be immunosuppressive through inhibition of lymphocyte egress from the thymus and lymph nodes.  As a result, agonists of this type hold promise as therapeutics for autoimmune disorders. In this communication, we report the discovery of novel S1P1 receptor agonists.

Novel S1P1 receptor agonists

244th National Meeting (2012)

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