Due to the variety of biological processes involved in the pathogenesis of cancer, combined therapies are usually used. In this context, targeting different anticancer modes of action in a single molecule is a challenge. Our interest in cannabinoid ligands and antiproliferative agents lies in developing molecules which structure includes cannabinoid and quinone features. Antineoplastic effects of quinones have been widely reported. On the other hand, increasing evidence showed that cannabinoids can modulate tumor growth, apoptosis and angiogenesis in various types of cancer. Herein, we report the synthesis of quinone derivatives of chromenopyrazoles. Their ability to bind to cannabinoid receptors was assessed through radioligand competition binding assays. Their antitumor activity was evaluated in vitro by human cancer cell cytotoxicity assays. In vivo human hepatocellular carcinoma and prostate cancer proliferation studies in mice are reported of one of them   .

Quinone derivatives of chromenopyrazoles as cannabinoid ligands with antitumor activity in vivo

244th National Meeting (2012)

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