Many theranostic systems depend on triggers from biologically-relevant stimuli, e.g. pH or reducing environments, to effect the release of a payload or the activation of imaging modalities. We have designed and synthesized a set of universal, stimuli-responsive organoalkyoxysilanes that are cleaved under acidic conditions or under reducing conditions for use with silica theranostic agents. These silanes contain either an azide or a terminal alkyne, making them reactive in the azide/alkyne �click� reaction with many potential payloads. We characterized the linkers using NMR and FTIR spectroscopies and have immobilized the linkers to silica particles. Also, we have tested the linkers' ability for triggered release in vitro. Moreover, we are interested in fluorine-containing groups for use in 19F MRI with �switch-on� imaging triggered by biological stimuli  . Thus, we have additionally developed cleavable and non-cleavable fluorine-containing alkoxysilanes for modifying silica particles with fluorine atoms.

Stimuli-responsive linkers for use in silica theranostic materials and application to <sup>19</sup>F MRI “switch-on” imaging

244th National Meeting (2012)

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Stimuli-responsive linkers for use in silica theranostic materials and application to 19F MRI “switch-on” imaging

Stimuli-responsive linkers for use in silica theranostic materials and application to ¹⁹F MRI “switch-on” imaging