Metal-catalyzed tandem coupling reactions with multifunctionalities are undoubtedly of importance to synthetic chemists for rapid synthesis of target compounds. However, one of the major hurdles for development of these reactions is very little information on the functionality preference of a catalyst, which dictates the identity of initial intermediate that can direct the key propagating species and the formation of the final product. As an effort to solve this fundamental issue, we determined the quantitative substituent effect on the preference of metathesis Ru catalysts to their functionalities, alkene, alkyne, and allene, using FRET-based method. In addition, we describe the relationships between functionality preference of the Ru catalyst and final product, derived from metathesis reactions with substituted alkenes, alkynes and allenes.

Quantitative substituent effect on the functionality preference of metathesis Ru catalysts and applications

244th National Meeting (2012)

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