The lack of resolution in current imagining techniques such as x-ray, optical, and magnetic nuclear imagining has excelled the development of new biosensor technologies. Cryptophane A can encapsulate xenon, making it an attractive biosensor candidate for detection by hyperpolarized xenon-129 MRI. One of the key challenges in developing Xe-biosensors is the need for water soluble cryptophane. Furthermore targeted imaging can be achieved by attaching a peptide to these molecules that will bind to receptors in the body. Herein we report the synthesis of water soluble cryptophane A with peptide linkers.

Development of water soluble cryptophane A for xenon biosensors

244th National Meeting (2012)

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