The design of new fluorescent dyes is an essential element in the development of probes and labels for biochemical research. Of special interest in this field are solvatochromic fluorophores, which display shifts in their absorption and emission bands induced by a change in the solvent nature or composition. Utilizing a concise synthetic route to naphthalene derivatives developed in our group, we designed and synthesized novel environmentally sensitive fluorescent dyes that show a significant bathochromic shift in their emission maximum upon an increase of the solvent polarity. With their unique properties, we expect these molecules to find a number of applications in biological science, clinical diagnosis and drug discovery.

Synthesis and photophysical properties of novel solvatochromic dyes

244th National Meeting (2012)

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