3-Aryl-1,2,4-triazin-6-ones are a class of fungicides that exhibit activity against a broad spectrum of agriculturally relevant pathogens, including Septoria tritici. Initial efforts to probe the SAR resulted in analogs with demonstrated curative activity but limited residual activity. A more comprehensive effort was undertaken to better understand the SAR and enhance potency and spectrum. Several directed approaches were taken to enhance the residual protectant activity of these molecules. The design, synthesis, and biological evaluation of these targeted molecules will be discussed.

Synthesis and SAR studies of fungicidal 3-aryl-1,2,4-triazin-6-ones

244th National Meeting (2012)

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