The unique photophysical properties of semiconductor quantum dots (QDs) are implemented to develop new biosensing platforms.  Functionalized QDs are used to follow enzyme activities, formation of immuno-complexes, DNA hybridization, aptamer-substrate interactions, and intracellular metabolic pathways.  Fluorescence resonance energy transfer, chemiluminescence resonance energy transfer, electron transfer and photocurrents are used as readout signals.Furthermore, fluorescent metallic nanoparticles (NPs) are deposited into predesigned DNA nanostructures and used as optical labels for the detection of DNA and cancer cells.  Also, DNA machines (DNA catenanes) are implemented as nanodevices for the programmed switchable assembly of Au NPs nanostructures.  The resulting nanostructures reveal unique switchable plasmonic properties.

Hybrid biomolecular/metallic (semiconductor) nanocrystals

244th National Meeting (2012)

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