There are no treatments to stop internal bleeding, yet immediate intervention is key for survival. We fabricated functionalized nanoparticles that can be administered intravenously to stop bleeding, and they reduced bleeding in both a femoral artery injury and blunt trauma model. We are investigating the relationship between the polymer structure, efficacy at halting bleeding, and clearance of the nanoparticles from tissues to optimize the systems and, hopefully, have a new treatment for internal bleeding. 

Nanoparticle to halt internal bleeding: Common biopolymers with uncommon outcomes

244th National Meeting (2012)

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