Pd(II)-catalyzed enantioselective and position-selective C�H  activation reactions are developed using mono-N-protected chiral amino acid ligands. C�H activation intermediates are characterized, offering insights into the origin of the observed stereoselectivity. Most importantly, these chiral ligands are found to accelerate drastically C�H activation reactions, shortening the reaction time from two days to 20 minutes.

Award Address  (Arthur C. Cope Scholar Award (CSM) sponsored by the Arthur C. Cope Fund). Accelerated C–H activation reactions: A shortcut to molecular complexity from chemical feedstock

244th National Meeting (2012)

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