Bimodal therapies aim to exploit complementary effects arising from the action of two species at the same site with the goal to optimize the therapeutic efficacy. Recently, nanoparticles of cationic amphiphilic �- cyclodextrins (cNPs) and non- ionic (niNPs) were proposed as effective anticancer1 and photosensitiser2 drug carriers, and for simultaneous photogeneration of therapeutic species.3 We here focus on niNPs for the dual delivery of docetaxel and zinc-phtalocyanine as system for the combination of chemotherapy and photodyanamic therapy in solid tumors. Morphological, spectroscopic and release properties, and interaction with relevant biological media were investigated. In vitro and in vivo potential of niNPs was assessed in different cell lines and an orthotopic animal model of breast cancer. AIRC-MFAG n� 8843 is gratefully acknowledged  References 1 Quaglia F et al, Biomaterials, 2009 , 30, 3742 Mazzaglia et al., Chemm Commun, 2011 , 47, 91403 Kandoth et al. Chem Eur J., 2012 , 18, 1684

Bifunctional cyclodextrin nanoparticles for combined approaches in the therapy of cancer

244th National Meeting (2012)

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