Bi-metallic organic frameworks (MOFs) are multi-topic ligands with a central atom. A well-known application of MOFs is hydrogen storage and carbon dioxide capture; however, it has recently been shown that many of the engineered MOFs can be applied for medical diagnostics and cancer therapy. The two goals are to: (1) conduct multidisciplinary project in the biological and physical sciences to develop new lines of diagnostics or cancer therapy tools; and (2) optimize the fabrication variables of MOFs. To accomplish the above goals, we have investigated the fabrication of nano-MOFs using feasible solvo-thermal approaches to formulate particles and characterize the nano-MOFs using state-of-the-art instrumentation; and to evaluate their in vitro cytotoxicity using model cell lines and hemocompatibility of MOFs with human red blood cells. The scope of this article will focus on introductory nanoscience, synthesis strategies and structural analysis techniques followed by specific examples related to diagnostics and cancer therapy.

Nanosized bimetallic metal-organic frameworks used for cancer diagnosis and therapy

244th National Meeting (2012)

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