Confining plasmonic nanoparticles to the cancer cell nucleus interferes with the cell cycle and induces DNA breaks. This interferes with the normal cell division and induces programmed apoptotic cell death. Confining photons to the small size of the plamonic nanoparticle greatly enhances their light scattering properties. This enable us to image the behavior of cancer cells during their cycles and as they die. The response of the community to the death of some is very different for gold1 nanoparticles targeting than for silver2 nanoparticle targeting. This is due to the difference in the death mechanism involved. The dependence of the efficiency of the apoptotic death mechanism on the plasmonic nanoparticle shape is observed and discussed. B Kang, M Mackay and M A El-Sayed, JACS Comm, 2010, 132 (5), p 1517.. L Austin, B Kang, M. El-Sayed, JACS Comm, 2011 , 133 (44), p17594.

Targeting cancer cell nuclei with plasmonic nanoparticles: Time dependent imaging of their behavior in life and in the process of dying

244th National Meeting (2012)

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