Here we discuss the development of a multifunctional plasmonic shell�magnetic core nanotechnology-driven approach for the targeted diagnosis, isolation, and photothermal destruction of multiple drug resistance bacteria (MDRB) and cancer cells. Experimental data show that bio-conjugated plasmonic/magnetic nanoparticles can be used for targeted imaging and magnetic separation of a particular kind of cell from a mixture of different cancer cells. Similarly we have also shown that bio-conjugated plasmonic/magnetic nanoparticles can be used for the separation of MDRB from other bacteria. A targeted photothermal experiment, using 670-nm light at 2.5 W/cm2 for 10 minutes resulted selective irreparable cellular damage to most of the cancer cells and MDRB bacteria. We also showed that the bio-conjugated magnetic/plasmonic nanoparticle-based photothermal destruction of cancer cells is highly selective. In this presentation, we will discuss the possible mechanism and operating principle for the targeted imaging, separation, and photothermal destruction using magnetic/plasmonic nanotechnology.

Multifunctional plasmonic–magnetic nanoparticles for targeted diagnostics, isolation, and photothermal destruction of tumor cells and MDRB bacteria

244th National Meeting (2012)

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