Pyrazole acetamides represent an active class of herbicides which have been known for over 30 years.  We have investigated a number of approaches to modify the core structure to design novel active herbicides.  Among these were amide replacement by heterocycles, constraining the aromatic ring in a ring and replacing the pyrazole with a 1,2,3-triazole.  Synthetic methods to prepare these compounds will be presented along with a summary of the biological activity and structure-activity relationships of this class.

Pyrazole-N-acetamides as starting points for herbicide discovery

244th National Meeting (2012)

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