We systematically evaluated, for the first time, the biting deterrent effects of a series of saturated and unsaturated fatty acids against Aedes aegypti using the K & D bioassay system. The saturated fatty acids (C6:0 to C16:0 and C18:0) and unsaturated fatty acids (C11:1 to C14:1, C16:1, C18:1, and C18:2) showed Biting Deterrence Index (BDI) values significantly greater than ethanol, the negative control. Among the saturated fatty acids, mid-chain length acids (C10:0 to C13:0) showed the highest biting deterrent activity against Ae. aegypti as compared to short chain length acids (C6: to C9:0) and long chain length acids (C14:0 to C18:0) except C8:0 and C16:0 where the activity was significantly higher than the other short and long chain acids. The in vivo treated-cloth-patch assay system results will also be discussed.

Mosquito biting deterrence: Structure-activity relationship of saturated and unsaturated fatty acids

244th National Meeting (2012)

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