The effects of plum polyphenols against some components of the metabolic syndrome were studied using cell models including adipocytes to determine effects in differentiation, fat accumulation and inflammation representing events in fat tissue. In addition, we studied inflammation in macrophage cells and Human umbilical vein endothelial cells (HUVEC) associated to atherosclerosis events. Results indicated that plum polyphenols have multiple functions and could potentially work against the metabolic syndrome in different fronts simultaneously. A rich anthocyanin extract (RAE) inhibited adipogenesis or lipid accumulation by modulating key transcription factors, c/EBPa Ppar? and Ppara and reduced the inflammatory response in adipocytes or fat cells by modulating transcription factor NFkB and gene expressions of different pro-inflammatory cytokines. On the other hand, chlorogenic acid inhibited the inflammatory response in macrophages and HUVEC cells by modulating transcription factor NFkB and gene expressions of different pro-inflammatory cytokines and adhesion molecules associated to chronic inflammation and atherosclerosis.

Plum fruit polyphenols differentially inhibit inflammation, and fat accumulation in cell models (adipocytes, macrophages, and HUVEC) associated to metabolic syndrome

244th National Meeting (2012)

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