Scouting around Pfizer's PI3 kinase inhibitor 1  (WO2010/038165), led to the discovery of imidazonapthyridine 2  with good fungicidal activity. A substantial optimization effort followed with many substitutions on the pyridine ring and imidazolone ring were explored for better fungicidal activity at lower application rates. Synthesis, biology, and structure activity relationships of imidazonapthyridines as well as the bicyclic quinoline central core 3  will be detailed.

PI3 kinase inhibitors as fungicides

244th National Meeting (2012)

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