Regulatory agencies require thorough environmental risk assessments (ERAs) of genetically modified (GM) crops such as those expressing insecticidal proteins.  ERAs typically follow a tiered approach for evaluating the potential adverse effects GM crops might have on the agroecosystems in which they will be cultivated.  Laboratory testing requires incorporation of test substances such as purified protein or GM plant material into artificial diets in order to evaluate their effects on non-target organisms relevant to the ERA.  Good laboratory practice (GLP) guidelines require homogeneity and stability of the test substance in the diet be established; however acceptability criteria are not well-defined.  Factors to consider for homogeneity and stability assessment of artificial diets�such as the need for validated analytical methods�as well as recommendations for establishing acceptability criteria, are discussed.

Establishing acceptability criteria for assessing the homogeneity and stability of test substances in artificial arthropod diets

244th National Meeting (2012)

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