Chardonnay is a white wine grape variety with seed high in polyphenolics (over 10% by weight), a class of compounds with known bioactivity.  Compared to male Syrian hamsters fed a high fat (HF) diet, animals fed a diet supplemented with flour made from chardonnay seeds (HFC) displayed a reduction in weight gain as well as lower blood lipid levels.  These improved physiological changes correlate with the observed up-regulation of hepatic genes related to cholesterol and bile acid synthesis (CYP51, HMGR, SREBP2, CYP7A1) when compared to control.  This suggests that the grape seed flour may reduce re-absorption of cholesterol and/or bile acid, therefore decreasing levels in the liver. Reduction in weight gain in the HFC group may be explained by hepatic gene up-regulation for fat oxidation (ACOX1) and down-regulation of fat synthesis (SCD1).  The expression of adipose genes related to inflammation and adipocytokine production were also analyzed.

Chardonnay grape seed flour reduces plasma lipids and increases expression of hepatic genes for cholesterol and fat synthesis in hamsters fed a high fat diet

244th National Meeting (2012)

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