The new TWD emulates average American intakes (at the NHANES 50th percentile) for micro- and macronutrients based on nutrient density. Mice were fed either TWD or AIN93G basal diets supplemented with or without 0.2% green tea extract in the drinking water. Green tea extract reduced bodyfat percentage in both the TWD and AIN93G groups (P < 0.05) and decreased fasting glucose levels in mice fed TWD (P = 0.02) but not AIN93G. Mice fed TWD without green tea had more ACF and a higher total crypt cell count compared to cohorts fed the AIN93G diet (P < 0.001).  Interestingly, green tea extract decreased ACF and total crypt cells in the TWD group (P < 0.001) but not in mice fed AIN93G.  These results suggest that the Western dietary pattern promotes carcinogenesis and that supplementation with chemopreventive bioactives, such as green tea, may be beneficial to populations consuming a poor diet.

Total Western Diet (TWD) increases azoxymethane induced aberrant crypt foci (ACF) compared to the AIN93G diet

244th National Meeting (2012)

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