In this study, a UV-filter, Benzophenone-3 (BP-3), was encapsulated in a mesoporous silica (MS). The BP-3 encapsulated MS (BP-3-MS) was prepared by the in-situ sol-gel polymerization of tetraethyl orthosilicate (TEOS) with an ionic liquid (IL) as a solvent and pore-forming agent and BP-3 as an additive. It was characterized by Fourier transformation infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), Differential Scanning Calorimetry (DSC), UV-Visible spectroscopy and in vitro sun protection factor (SPF) measurement. The results showed that the amount of BP-3 encapsulated in MS was about 38~46wt% of BP-3-MS. Comparing to that of the free BP-3, the dispersion of BP-3-MS in the water-base sunscreen cream was significantly improved. Beside, the SPF value of the BP-3-MS-containing sunscreen cream was also increased, indicating that the UV protection ability of the sunscreen cream was enhanced due to the encapsulation of BP-3 by the MS matrix. In addition, the BP-3 release in triglyceride was largely decreased after encapsulation by the MS, implying a possibility of reduction in the percutaneous penetration of BP-3 for the BP-3-MS-containing sunscreen.

Enhanced effectiveness of sunscreen BP-3 after encapsulation by mesoporous silica oxide

244th National Meeting (2012)

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