Cancer is the second most frequent cause of death in Jordan. There are various types of treatment for cancer patient, these include: chemotherapy, radiation therapy, surgery and other miscellaneous methods. Several drugs have been developed for cancer treatment especially in the chemotherapy. However, the side effects of these drugs were severe since it mainly does not recognize cancer cells from normal ones. Due to this, it is vital to develop methods that specifically target cancer cells and hence minimizing normal cells exposure to these dangerous drugs. Aptamers (which are nucleic acid macromolecule that binds tightly to a specific molecular target and induce changes on the genetic levels which will lead eventually to cancer cells death) will be selected to bind with certain targets using SELEX. In this project, it is our aim to study and develop vehicles for targeted-delivery of macromolecular drugs.

Targeted-delivery of macromolecular drugs (aptamers) to cancer cells using liposomes

244th National Meeting (2012)

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