A multilevel antimicrobial coating based on contact-killing, release-killing and anti-adhesion strategy was developed based on encapsulated chlorine dioxide. The use of smart polymers enables the coating to response to touch and contamination by self-disinfection. Laboratory tests show the coating can render nonviable within 1 minute contact viruses (H1N1, RSV, EV-71), Gram-positive and Gram-negative bacteria. It is also effective against bacteria and fungal spores. The mechanism of inactivation is through oxidation of microbial outer coating and oxidative reactions with proteins and DNA.The multilevel antimicrobial coating was field tested in hospital environment. Study were carried out at three Hong Kong public hospitals to evaluate safety, efficacy and compatibility of coating materials applied to medical items and hospital furnishings under real working conditions. The results indicate that the coating can render low viability of bacteria on surfaces for prolonged period of time. Thus, demonstrating the applicability of the coating in clinical situation.

Performance of multilevel antimicrobials in clinical environment

244th National Meeting (2012)

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