The successful development of new synthetic methods and catalysts is important for the discovery and production of chiral organic molecules and materials. Silanols offer new opportunities as activating groups for enantiocontrol based on their hydrogen bonding abilities. This lecture will describe the synthesis and development of organic silanols and silanediols for new hydrogen-bonding catalysts.  Specifically, the cooperative hydrogen-bonding effects of silanediols will be discussed.  Applications of these catalysts for carbon-carbon bond-forming reactions and enantioselective synthesis will be presented. This lecture will also discuss structural studies, mechanism, and molecular insights for catalyst activity and design.

Hydrogen-bonding properties of organic silanols for asymmetric catalysis

244th National Meeting (2012)

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