Redox-neutral reactions are powerful tools for rapidly building molecular complexity and shortening synthetic sequences by avoiding reduction and oxidation steps.  We will discuss our recent progress on the mild functionalization of C�H bonds alpha to nitrogen.  The combination of a reductive N-alkylation with an oxidative a-functionalization leads to overall redox-neutral transformations.  Azomethine ylides are intermediates in these processes that allow for the direct a-cyanation and a-alkynylation of amines.

Redox-neutral α-functionalization of amines

244th National Meeting (2012)

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