In order to obtain an accurate description of nanocarrier dynamics in the bloodstream and near wall interactions, we have developed a formalism where both the Brownian motion as well as the hydrodynamic interactions are important. We employ a direct numerical simulation adopting an arbitrary Lagrangian-Eulerian based finite element method to simulate the Brownian motion of nanocarrier in an incompressible Newtonian fluid. Thermal fluctuations are implemented using two dierent approaches: (1) fluctuating hydrodynamics approach; (2) generalized Langevin appproach. At thermal equilibrium, the numerical predictions for temperature of the nanoparticle, velocity distribution of the particle, decay of the velocity autocorrelation function, diffusivity of the particle and particle-wall interactions in the presence and absence of adhesive interactions are computed for various flow conditions.

Modeling of nanoparticle motion in an incompressible Newtonian fluid: A comparison between fluctuating hydrodynamics and generalized Langevin approaches

244th National Meeting (2012)

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