Synthetic Immunology, the development of synthetic systems capable of modulating and/or manipulating immunological functions, represents an emerging field of research with manifold possibilities.  Our laboratory's work in this area has included efforts to create low molecular-weight synthetic species, called antibody-recruiting molecules (ARMs), which are capable of enhancing antibody binding to disease-relevant cells or viruses, thus leading to immune-mediated clearance of these targets.  This presentation will describe the development of ARM technologies with a particular emphasis on applications related to infectious agents, including HIV and Staph. aureus.  In addition to exploring the potential therapeutic utility of ARMs and related structures, these research efforts have led to a number of unexpected scientific discoveries.  Hopefully this presentation will provide insight into the many exciting research possibilities at the interface of organic chemistry, immunobiology, and infectious disease.

Using small molecules to engineer and explore immune responses to infectious agents

244th National Meeting (2012)

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